For the last 11 years now, I have been handling, looking after my children, working from home, and dealing with household chores pretty much on my own, and I will be the first to say that it was stressful and I had times where I felt I couldn't cope.
Now that my kids are older, they tend to help with the household chores, especially when I am working and that helps a lot with stress related to having to deal with everything.
It is always wise to either have your partner take half of the chores around the home that need doing, or if you are a single parent, find fun ways to get your children involved in household chores to help lessen the stress and the pressure.